科学60秒:杂交葡萄柚打破与药物的互动
全文听写:本文有科学家说话哦
Hints:
furanocoumarins
the University of Florida
pummelo
Fred Gmitter
the Journal of the American Society for Horticultural Science Grapefruits are off-limits for people on certain medications. The tangy fruits contain compounds called furanocoumarins, which can dangerously increase the effective dosage of some blood pressure and heart medications. But scientists at the University of Florida have bred a new type of grapefruit that should enable people on meds to enjoy the fruit without the drug interaction. "There are certain relatives of grapefruit that we call pummelo, some of which are very, very low or have no furanocoumarins in them at all. And we've crossed these with ordinary grapefruit." Fred Gmitter, a citrus geneticist at the University of Florida. These new hybrid grapefruits have even less of the compounds than do other foods that don't get special warnings. "Doctors don't generally tell their patients not to drink lemonade or not to eat celery. So these should be as safe or safer than lemons or celery." The findings are described in the Journal of the American Society for Horticultural Science. The new fruits are also seedless. Which should make them an easy switch for consumers to swallow.Hybrid Grapefruit Busts Drug Interactions 杂交葡萄柚打破与药物的互动 普通的葡萄柚含有一种物质,因此能弱化一些药效。一种新型杂交品种解决这个问题。 正在服用某些药物的患者需要限制食用葡萄柚。这种重口味的水果中含有一种名叫 呋喃并香豆素 的化合物,它对一些作用于 血压和心脏类 药物使用的有效剂量会有严重的影响。 但佛罗里达大学的科学家们已经培育出一种新型杂交葡萄柚品种,这样就可以使得正在进行相关治疗的人能够享用这种水果而不必担心会与自己使用的药物产生冲突作用。 佛罗里达大学的柑橘类植物遗传学家 Fred Gmitter :“葡萄柚类水果中有个品种我们称之为柚子,其中又有一些品类含有很少甚至不含这类化合物成分。因此我们把这类品种的柚子与普通的葡萄柚进行了杂交研究。” 这些新型杂交葡萄柚品种甚至含有比其它植物类食物还要更少的这类化合物,因此更加不用担心啦。因为医生们通常都不会这样叮嘱患者:“小心饮用柠檬水或者不要吃芹菜”,所以这个新型杂交品种应该和柠檬啊、芹菜之类的食物同样安全,或更安全呢~ 这项研究结果已经发表在美国社会期刊的园艺科学栏目中。 这种新型水果还是无籽的呢~更方便广大消费者食用了~ —Katherine Harmon ---------------------by hyjtb Special : Furanocoumarins 或者 furocoumarins (呋喃并香豆素),是一类许多种类的植物中都能产生的有机化合物,并且大部分都是有毒的。植物是基于抵抗小到昆虫,大到哺乳类等广泛的多种类的捕食者而形成的抵抗机制起作用而产生的这类物质[1]。 对于人类,这类物质存在的果汁会对某些化合类药物的代谢产生影响[2]。 [1] ^ Professor May Berenbaum's research page - University of Illinois at Urbana-Champaign [2] 6′7′-Dihydroxybergamottin Contributes to the Grapefruit Juice Effect*6′7′-Dihydroxybergamottin Contributes to the Grapefruit Juice Effect Pharmacokinetics and Drug Disposition Clinical Pharmacology & Therapeutics 75, 569-579 (June 2004) | doi:10.1016/j.clpt.2004.02.007